Multiple Imputation for Missing Data: Fully Conditional Specification Versus Multivariate Normal Imputation

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Multiple imputation for missing data: fully conditional specification versus multivariate normal imputation.

Statistical analysis in epidemiologic studies is often hindered by missing data, and multiple imputation is increasingly being used to handle this problem. In a simulation study, the authors compared 2 methods for imputation that are widely available in standard software: fully conditional specification (FCS) or "chained equations" and multivariate normal imputation (MVNI). The authors created ...

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The use of the Gibbs sampler with fully conditionally specified models, where the distribution of each variable given the other variables is the starting point, has become a popular method to create imputations in incomplete multivariate data. The theoretical weakness of this approach is that the specified conditional densities can be incompatible, and therefore the stationary distribution to w...

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Missing data commonly occur in large epidemiologic studies. Ignoring incompleteness or handling the data inappropriately may bias study results, reduce power and efficiency, and alter important risk/benefit relationships. Standard ways of dealing with missing values, such as complete case analysis (CCA), are generally inappropriate due to the loss of precision and risk of bias. Multiple imputat...

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ژورنال

عنوان ژورنال: American Journal of Epidemiology

سال: 2010

ISSN: 0002-9262,1476-6256

DOI: 10.1093/aje/kwp425